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目的探讨重症感染患儿抗生素相关性腹泻(AAD)的发病及抗生素使用情况。方法回顾性分析166例重症感染患儿的临床资料,总结和探讨重症感染患儿AAD的发病率、抗生素使用情况。结果 166例患儿中,发生AAD 92例(55.4%);引发AAD的常见抗生素为头孢菌素。AAD患儿年龄、抗生素使用时间、种类、基础疾病与非AAD患儿比较差异均有统计学意义(P<0.05)。结论重症感染患儿AAD发病率较高,与年龄、抗生素使用时间、种类、基础疾病相关。
Objective To investigate the incidence of antibiotic-associated diarrhea (AAD) and antibiotic use in children with severe infections. Methods A retrospective analysis of 166 cases of severe infection in children with clinical data to summarize and explore the incidence of AAD in children with severe infection, antibiotic use. Results Of the 166 children, 92 (55.4%) had AAD and the common antibiotic causing AAD was cephalosporin. AAD children with age, duration of antibiotic use, type, basic disease and non-AAD children were significantly different (P <0.05). Conclusions The incidence of AAD in children with severe infection is higher than that of age, antibiotic use time, type and underlying diseases.