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目的探讨空气中细颗粒物(PM2.5)与健康年轻人血浆血管性血友病因子(vWF)水平的相关性。方法招募114名在北京大学第一医院生活与工作的健康年轻人,于奥运会前、中和后期,每名受试者各采集血标本2次,共6次,用于血浆vWF的测定,每日PM2.5的浓度由北京大学环境科学与工程学院测定,对应血标本分为6个时段。结果第1时段(6月10—23日)、第2时段(6月24—7月7日)、第3时段(8月4—15日)、第4时段(8月18日—29日)、第5时段(10月6—17日)、第6时段(10月20—30日)PM2.5的平均值分别为101.841 0、101.857 0、87.147 0、71.687 0、87.470 0和76.107 8μg/m3,对应阶段的血浆vWF平均值分别为103.933 0%、100.160 0%、91.704 0%、85.022 0%、88.460 0%和76.353 3%;血浆vWF水平与vWF测定前0~5 d PM2.5浓度的相关系数分别是-0.132(P=0.332)、0.110(P=0.414)、0.197(P=0.142)、0.224(P=0.097)、0.320(P=0.017)和0.156(P=0.256),表明PM2.5对血浆vWF水平的影响具有4 d的滞后效应(P<0.05)。结论 2008年北京奥运会期间,受试者血浆平均vWF水平降低与PM2.5降低具有相关性。
Objective To investigate the correlation between PM2.5 in air and plasma vWF in healthy young people. Methods A total of 114 healthy young people living and working in the First Hospital of Peking University were recruited. Before and during the Olympic Games, each subject collected blood samples twice for 6 times, and used for the determination of vWF in plasma. PM2.5 concentrations measured by the College of Environmental Science and Engineering, Peking University, corresponding to the blood specimen is divided into 6 periods. Results The first period (June 10-23), the second period (June 24-7 July), the third period (August 4-15), the fourth period (August 18-29 ), The average value of PM2.5 in the fifth period (October 6-17) and the sixth period (October 20-30) were 101.841 0, 101.857 0, 87.147 0, 71.687 0, 87.470 0 and 76.107 8 μg / m3 and the average plasma vWF in the corresponding phase was 103.933%, 100.160%, 91.704%, 85.0%, 88.4% and 76.353%, respectively. The plasma levels of vWF were positively correlated with the levels of PM2.5 The correlation coefficients of concentration were -0.132 (P = 0.332), 0.110 (P = 0.414), 0.197 (P = 0.142), 0.224 (P = 0.097), 0.320 (P = 0.017) and 0.156 (P = 0.256) The effects of PM2.5 on plasma vWF levels had a lag effect of 4 days (P <0.05). Conclusions During the 2008 Beijing Olympic Games, the decrease of plasma mean vWF level in subjects was correlated with the decrease of PM2.5.