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新生儿接种乙肝疫苗后,极少数人既无免疫应答(抗HBs<10mlU/ml),又无血清乙肝病毒(HBV)感染标记,但却可在血清中查到乙肝病毒脱氧核糖核酸(HBVDNA),提示已具有HBV 隐匿感染。同时,无应答的婴儿血抗CMV-IgM 及抗CMV-IgG 双阳率(32.05%)明显高于对疫苗有正常应答(抗HBs≥10mIU/ml)的婴儿(15.22%),提示人巨细胞病毒(HCMV)感染且有活动可干扰抗HBs 的产生。
Very few people have no immune response (anti-HBs <10 mlU / ml) and no serum HBV markers but can detect HBV DNA (HBV DNA) in their serum after the newborn is vaccinated with hepatitis B vaccine. , Suggesting that it has hidden HBV infection. At the same time, the non-responding infantile anti-CMV-IgM and anti-CMV-IgG double positive rate (32.05%) were significantly higher than that of the infants (15.22%) with normal response to the vaccine (anti HBs≥10mIU / ml), suggesting that human cytomegalovirus (HCMV) infection and activity can interfere with anti-HBs production.