Ｌｅｐｔｉｎ是肥胖基因（ｏｂ ｇｅｎｅ）表达的蛋白质产物，主要产生于脂肪组织，向大脑反馈能量储存的信息并激活下丘脑中枢调节摄食和能量的消耗。此外， ｌｅｐｔｉｎ还可影响神经内分泌机制，调节多种下丘脑垂体靶腺轴。肥胖基因表达和ｌｅｐｔｉｎ浓度受多种因素的调控，本文就ｌｅｐｔｉｎ的分泌和调节的生物学作用及在不同的生理和病理状态下的作用机制等方面的进展作一综述。 Leptin, a protein product expressed by the ob gene, is mainly produced in adipose tissue, feeds back energy storage information to the brain and activates the hypothalamic center to regulate feeding and energy expenditure. In addition, leptin can also affect the neuroendocrine mechanism, regulating a variety of hypothalamic pituitary gland axis. Obese gene expression and leptin concentration are regulated by many factors. In this paper, we review the biological roles of leptin in secretion and regulation, and their roles in different physiological and pathological conditions.