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目的 了解 p5 3、pgp相关性及其对进展期大肠肿瘤患者化疗及预后的影响。 方法 3 8例进展期大肠肿瘤患者标本 ,通过免疫组化技术检测 p5 3、pgp表达情况 ,所有患者均经临床密切随访。结果 3 8例患者中 ,p5 3表达阳性 2 3例 ,阴性 15例 ,pgp表达阳性 18例 ,阴性 2 0例 ,二者均阳性者 10例。将患者分为化疗组及对照组后发现 ,化疗组 p5 3、pgp阳性率明显高于对照组 ,且二者均阳性者 ,局部复发率或转移率可达 73 .3 3 % (11/15 ) ,明显高于二者均阴性者 (16.7% ,2 /12 )。结论 p5 3、pgp有一定相关性 ,二者均阳性表达者临床预后差 ,且 pgp的表达与临床化疗亦有一定关联。
Objective To understand p5 3, pgp correlation and its effect on chemotherapy and prognosis of patients with advanced colorectal cancer. METHODS: Thirty-eight patients with advanced colorectal tumors were examined for the expression of p53 and pgp by immunohistochemistry. All patients were followed closely by the clinic. Results Among the 38 patients, p53 expression was positive in 23 cases, negative in 15 cases, pgp expression in 18 cases, and negative in 20 cases. Both cases were positive in 10 cases. After the patients were divided into chemotherapy group and control group, the positive rates of p53 and pgp were significantly higher in the chemotherapy group than in the control group, and the positive rate of the two groups was 73.33% (11/15). ), significantly higher than those who were negative (16.7%, 2/12). Conclusion There is a certain correlation between p53 and pgp. The positive expression of p53 and pgp have poor prognosis. The expression of pgp is also related to clinical chemotherapy.