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目的:观察自拟消幽汤治疗幽门螺杆菌(Hp)阳性湿热型十二指肠溃疡患者的临床疗效,探寻一个临床症状及胃镜改善明显、根治率高、副作用小、并能提高人体全身免疫力且又价廉的确实可行的中西医结合治疗方案。方法:将符合纳入标准的(门诊或住院)60病例,随机分为治疗组和对照组(按就诊顺序编号:奇数列入治疗组,偶数列入对照组)。治疗组口服中药消幽汤(黄连、法半夏、黄芩、蒲公英、豆蔻、枳壳、陈皮、茯苓、百合、浙贝、丹参、砂仁、木香、甘草,按一定比例组方。)煎剂内服,同时加服西药奥美拉唑、阿莫西林、克拉霉素治疗,对照组:单用奥美拉唑、阿莫西林、克拉霉素。记录两组患者治疗前后的临床症状、胃镜下的疗效、根除Hp情况的临床观察,对临床疗效进行评价。结果:治疗组在临床症状缓解、胃镜下疗效、Hp根除率及复发率、副作用的发生上优于对照组(P《0.05),两组间比较有统计学差别。结论:运用消幽汤治疗幽门螺杆菌(Hp)阳性湿热型十二指肠溃疡,有比较确切的疗效,中西医结合治疗溃疡效果优于单纯西药治疗,消幽汤的治疗作用机理可能通过整体调整机体免疫功能、抑酸、保护胃粘膜、抗Hp及调节粘膜微循环而实现的。
Objective: To observe the curative effect of self-made Xiaoyou Decoction in treating H.pylori-positive duodenal ulcer patients and to find out a clinical symptom and gastroscope to improve obviously, high cure rate, little side effect and to improve body’s immunity And cheap and practical combination of traditional Chinese and Western remedies. Methods: Sixty cases (outpatient or inpatient) who met the inclusion criteria were randomly divided into treatment group and control group (numbered according to the order of treatment: odd numbers were included in the treatment group and even numbers were included in the control group). The treatment group oral Chinese Xiao You Tang (Coptis, France Pinellia, skullcap, dandelion, cardamom, Citrus aurantium, dried tangerine peel, Poria, Lily, Zhejiang shellfish, Salvia, Amomum, woody, licorice, according to a certain proportion of the group Oral administration, while taking Western medicine omeprazole, amoxicillin, clarithromycin treatment, the control group: omeprazole alone, amoxicillin, clarithromycin. The clinical symptoms before and after treatment, the efficacy under gastroscope and the clinical observation of eradication of Hp were recorded, and the clinical efficacy was evaluated. Results: The treatment group was better than the control group in relieving clinical symptoms, endoscopic efficacy, Hp eradication rate, recurrence rate and side effects (P <0.05). There was a significant difference between the two groups. Conclusion: The use of Xiaoyou Decoction in the treatment of Helicobacter pylori (Hp) -positive damp-heat duodenal ulcer has a more exact effect. Integrative treatment of ulcer is superior to western medicine alone. The therapeutic mechanism of Xiaoyou decoction may be through the whole Adjust the body’s immune function, inhibit acid, protect the gastric mucosa, anti-Hp and regulate mucosal microcirculation and achieve.