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[目的 ]了解全细胞百白破三联制剂 (DTwP)与无细胞百白破三联制剂 (DTaP)的接种副反应。 [方法 ] 2 0 0 1～2 0 0 2年在薛城区卫生防疫站预防接种门诊采用单盲法将 1118名 3～ 6月龄儿童及 60 6名 18～ 2 4月龄儿童分成 2组。基础免疫儿童一组 763人接种DTwP ,另一组 3 5 5人接种DTaP ;加强免疫儿童一组 2 61人接种DTwP ,另一组 3 45人接种DTaP。 [结果 ]副反应发生率DTwP组为 2 2 66% ,DTaP组为 3 5 7% ;发热反应率DTwP组为 2 2 3 6% ,DTaP组为3 43 % ;接种部位红肿或硬结发生率DTwP组为 2 1 3 9% ,DTaP组为 3 5 7%。以上反应发生率均为DTwP组高于DTaP组 ,差异均有统计学意义 (P <0 0 1)。随针次增加 ,接种反应率增加 ,差异有统计学意义 (P <0 0 5 )。 [结论 ]DTaP的接种安全性优于DTwP ;针次增加 ,接种反应率增加。
[Objective] To understand the inoculation side effects of DTwP and DTaP. [Methods] From 2001 to 2002, 1118 children aged 3 to 6 months and 606 children aged 18 to 24 months were divided into two groups using the single-blind method in the vaccination clinic of Xuecheng District Health and Anti-epidemic Station. A group of 763 immunized children received DTwP and another 355 received DTaP. A group of 2161 immunized children received DTwP and another group of 45 infants received DTaP. [Results] The incidence of side effects was 22 66% in the DTwP group and 35.7% in the DTaP group. The incidence of fever was 22 43% in the DTwP group and 433% in the DTaP group. The incidence of inflamed or indurated DTwP The group was 21.39% and the DTaP group was 35.7%. The incidence of these reactions were higher in DTwP group than in DTaP group, the difference was statistically significant (P <0.01). With the increase of the number of needle inoculation, the response rate increased, the difference was statistically significant (P <0 05). [Conclusion] The vaccination safety of DTaP is better than that of DTwP; the number of injections increases, and the inoculation response rate increases.