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目的探讨硫普罗宁在抗结核药物肝损伤中的保护作用。方法 2011年3月至2013年3月期间,本院诊治的64例抗结核药物肝损伤患者,根据随机数字法,将其分为对照组(常规护肝药物)和观察组(硫普罗宁),每组各32例,对两组治疗后总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、白蛋白(ALB)等肝功能指标,以及不良反应,进行观察和比较。结果与对照组相比,观察组治疗后TBIL、ALT、ALB水平均明显降低,P<0.05,差异有统计学意义。治疗期间,两组都没有出现明显的不良反应。结论硫普罗宁治疗抗结核药物肝损伤的疗效显著,明显改善患者肝功能,值得临床推广。
Objective To investigate the protective effect of tiopronin in the anti-TB drug-induced liver injury. Methods From March 2011 to March 2013, 64 patients with anti-TB drug-induced liver injury treated in our hospital were divided into control group (conventional liver protection drug) and observation group (tiopronin) according to random number method. (N = 32). The liver function indexes such as total bilirubin (TBIL), alanine aminotransferase (ALT) and albumin (ALB), as well as adverse reactions of the two groups were observed and compared after treatment. Results Compared with the control group, the levels of TBIL, ALT and ALB in the observation group decreased significantly (P <0.05), and the difference was statistically significant. During treatment, no apparent adverse reactions occurred in both groups. Conclusion The effect of tiopronin in treating liver damage caused by antituberculosis drugs is significant, and the liver function of patients is obviously improved, which is worthy of clinical promotion.