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EB 病毒(EBV)是从非洲儿童的恶性淋巴瘤细胞培养中发现的一种嗜人 B 淋巴细胞的疱疹病毒。该病毒在正常人群中的感染非常普遍,绝大部分感染者为健康携带状况。但国内外大量研究表明,EBV 与 Burkitt 淋巴瘤、霍奇金淋巴瘤、鼻咽癌等多种肿瘤发生有关。然而,最新文献证实,最初用于霍奇金淋巴瘤免疫组化检测 EBV 核抗原(EBNA)抗体2B4与 MAGE-4存在交叉反应,因而对基于该抗体免疫组化检出的 EBV 与某些肿瘤相关的结论产生质疑,提出 EBV 不是乳腺癌病因的观点。此外,EBV 特异性细胞毒性 T 淋巴细胞(CTL)治疗同种异体造血干细胞移植后发生淋巴组织增生性疾病效果明显,而在其他 EBV 相关肿瘤治疗方法和
Epstein-Barr virus (EBV) is a human herpes B-cell herpes virus found in the culture of malignant lymphoma cells from African children. The virus infection in the normal population is very common, the vast majority of infected persons for healthy carrying status. However, a large number of studies both at home and abroad show that EBV is associated with a variety of tumors such as Burkitt’s lymphoma, Hodgkin’s lymphoma and nasopharyngeal carcinoma. However, the latest literature confirms that EBV antibody 2B4, originally used in the detection of Hodgkin’s lymphoma by immunohistochemistry, cross-reacts with MAGE-4. Therefore, EBV detected by immunohistochemistry of this antibody is associated with some tumors Relevant conclusions have been questioned, suggesting that EBV is not the cause of breast cancer. In addition, EBV-specific cytotoxic T lymphocytes (CTLs) have been shown to be effective in treating lymphoproliferative diseases after allogeneic hematopoietic stem cell transplantation. However, in other EBV-related tumor therapies and