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目的通过8-异前列腺素F2α(8-iso-PGF)2α探讨老年2型糖尿病合并低T3综合征与氧化应激的关系。方法新诊断老年2型糖尿病患者167例,分为单纯糖尿病组85例和糖尿病合并低T3综合征组82例,同时选取健康体检者80例作为对照组。检测游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、8-iso-PGF2α、糖化血红蛋白(Hb A1c)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果各组间年龄、体重指数(BMI)、TC、FT4、TSH差异无统计学意义(P>0.05);单纯糖尿病组、糖尿病合并低T3综合征组8-iso-PGF2α、HBA1c、TG、HDL-C、LDL-C均高于健康对照组,FT3低于健康对照组(P<0.05)。进一步进行多元逐步回归分析显示,年龄、8-iso-PGF2α是影响2型糖尿病发生低T3综合征的重要因素(B=-0.023、-0.005;P=0.028、0.000)。结论氧化应激可能与2型糖尿病患者发生低T3综合征有关。
Objective To explore the relationship between oxidative stress and type 2 diabetes mellitus with low T3 syndrome in aged patients with 8-iso-prostaglandin F2α (8-iso-PGF) 2α. Methods A total of 167 newly diagnosed type 2 diabetic patients were divided into two groups: diabetes mellitus group (85 cases) and diabetes mellitus (82 cases) with low T3 syndrome group. Eighty healthy subjects were selected as control group. The levels of free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), 8-iso-PGF2α, Hb A1c, triglyceride and total cholesterol ), High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Results There were no significant differences in age, body mass index (BMI), TC, FT4 and TSH between the groups (P> 0.05). The levels of 8-iso-PGF2α, HBA1c, TG and HDL in diabetes mellitus with low T3 syndrome C, LDL-C were higher than the healthy control group, FT3 lower than the healthy control group (P <0.05). Further stepwise multiple regression analysis showed that age, 8-iso-PGF2α, was an important factor influencing the occurrence of low T3 syndrome in type 2 diabetes (B = -0.023, -0.005; P = 0.028,0.000). Conclusion Oxidative stress may be related to the occurrence of low T3 syndrome in type 2 diabetic patients.