论文部分内容阅读
比较了七种海藻多糖在体外抑制人食管癌细胞株(EC109)的生物活性.结果表明,浓度为100毫克/毫升的不同多糖作用48小时后均出现明显抑制,细胞大部分脱落.抑制率在75～95％之间;当浓度为50毫克/毫升作用后抑制率维持在30％以上;25毫克/毫升以下浓度的鼠尾藻多糖仍表现出显著的抑制效果. 各种多糖对组织环化腺苷酸磷酸二酯酶(cAMP-PDE)的体外抑制表明,唯有褐藻淀粉硫酸酯对兔脑cAMP-PDE活性有明显作用,抑制率达74.5％.
The biological activities of seven kinds of seaweed polysaccharides in vitro against human esophageal cancer cell strains (EC109) were compared. The results showed that the effects of different polysaccharides at a concentration of 100 mg/ml were significantly inhibited after 48 hours and most of the cells were detached. Between 75 and 95%; the inhibition rate was maintained above 30% when the concentration was 50 mg/ml; the polysaccharides below 25 mg/ml showed a significant inhibitory effect on the polysaccharides. In vitro inhibition of adenylate phosphodiesterase (cAMP-PDE) showed that only the brown algae starch sulfate had a significant effect on the cAMP-PDE activity of rabbit brain, and the inhibition rate was 74.5%.