Carlson等(1968)提出前列腺素E(PGE)在偏头痛发作中可起作用。Welch等(1974)发现PGE有扩张颈外动脉和增加其血流量的作用,并通过“盗血”机制而减少颈内动脉的血流量,这些作者认为偏头痛是由颈外动脉局部释放前列腺素使之扩张而引起。另有人(1972)报告前列腺素F_2α可强烈收缩颅 Carlson et al. (1968) suggested that prostaglandin E (PGE) may play a role in migraine attacks. Welch et al. (1974) found that PGE has the effect of expanding and increasing the blood flow of the external carotid artery and reducing the blood flow of the internal carotid artery by a “steal” mechanism. These authors believe that migraine is the local release of prostaglandin by the external carotid artery To cause expansion. Others (1972) reported that prostaglandin F_2α strongly contracted the skull