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目的了解鲁西南地区肝病患者中五型肝炎病毒感染的分布，及重叠感染的影响。方法用ＥＬＩＳＡ法检测３１１例各类肝病患者血清五型肝炎病毒标志物，对感染模式与临床类型的关系进行分析研究。结果本组五型肝炎病毒均有感染，以ＨＢＶ感染最多（８７．８％）。共有１３种感染模式，其中单一病毒感染２０４例（６５．６％），重叠感染１０３例（３３．１％），原因不明４例（１．３％）。各临床类型的重叠感染率存在非常显著差异（Ｐ＜０．００５），以ＨＢｓＡｇ携带者最低（０），重症肝炎组最高（６６．７％）。结论肝炎病毒重叠感染与病情轻重、迁延、活动及恶化密切相关
Objective To understand the distribution of hepatitis C virus (HBV) infection in patients with liver disease in southwestern Shandong and the influence of overlapping infection. Methods The serum markers of hepatitis C virus in 311 cases of various liver diseases were detected by ELISA. The relationship between infection patterns and clinical types was analyzed. Results All of the five hepatitis viruses were infected and HBV infection was the most (87.8%). There were 13 infection patterns, of which 204 (65.6%) had single virus infection, 103 (33.1%) had overlapping infection and 4 (1.3%) had unknown cause. There was a significant difference (P <0.005) in the prevalence of overlapping infections between different clinical types, with the lowest in HBsAg carriers (0) and the highest in severe hepatitis group (66.7%). Conclusions Hepatitis C virus overlap infection is closely related to severity, delay, activity and exacerbation