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很多株甲型流感病毒在体外对鼠B淋巴细胞有促分裂活性。一些资料指出在促分裂过程中,血凝素(HA)分子起重要作用,而神经氨酸酶(NA)不影响分裂活性。问题是仅有HA的作用是否足以传递促分裂的信息。ArmsTrong等报告以菠萝蛋白酶处理流感病毒所获得的HA(Brom HA)具有促分裂活性,甚至得自很少或没有促分裂活性的H_1亚型甲型病毒或乙型病毒的HA也是如此。但他们没有考查Brom HA究竟是对T细胞还是对B细胞作用,因此不清楚BromHA的促分裂作用能否反映病毒的促分裂作用。
Many strains of influenza A virus have in vitro murine B lymphocyte mitogenic activity. Some data indicate that hemagglutinin (HA) molecules play an important role in mitosis, whereas neuraminidase (NA) does not affect the activity of division. The question is whether the effect of HA alone is sufficient to pass on mitogenic information. ArmsTrong et al. Report that mitochondria HA (Brom HA) obtained by the bromelain treatment of influenza virus has mitogenic activity even from HA of the Hl subtype A or B viruses with little or no mitogenic activity. However, they did not test whether Brom HA actually affects T cells or B cells, so it is unclear whether the mitogenic effects of BromHA reflect the mitogenic effects of the virus.