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多肽的释放是临床应用的关键。大多数多肽是有较强极性,极易消化的大分子。口服或经皮给药吸收较差,而且药物的半衰期短。为此可采用多肽化学结构修饰的手段弥补。本文报道了牛胰岛素棕榈酰化及棕榈酰胰岛素类似物的生物活性。
Peptide release is the key to clinical application. Most peptides are highly polar, easily digested macromolecules. Oral or transdermal administration is poorly absorbed, and the half-life of the drug is short. This can be used to modify the chemical structure of peptide means to make up. This article reports the bovine insulin palmitoylation and the bioactivity of palmitoyl insulin analogues.