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1.33只家兔进行尾核头部推挽灌流,测得 cAMP 的基础释放量为每分钟0.57±0.065×10_(-12)M。2.家兔电针后,在痛阈升高的同时尾核灌流液中 cAMP 含量降低。这二种作用均可被纳洛0.4毫克/公斤静脉注射所逆转。3.电针前2分钟,静脉注射 L-DOPA20毫克/公斤,使电针针效和尾核灌流液中 cAMP降低作用均减弱。4.电针前2分钟,静脉注射氟哌啶醇2毫克/公斤能加强电针镇痛,但1或2毫克/公斤的氟哌啶醇对家兔电针后尾核中 cAMP 降低作用均无明显影响。
1.33 rabbits were subjected to push-pull perfusion of caudate nucleus. The basal release of cAMP was 0.57 ± 0.065 × 10 (- 12) M per minute. Rabbits after electroacupuncture in the pain threshold increased at the same time cAMP content of caudate nucleus perfusate decreased. Both of these effects could be reversed by intravenous injection of 0.4 mg / kg naloxone. 3 minutes before electroacupuncture intravenous injection of L-DOPA 20 mg / kg, the electroacupuncture needle effect and caudate nucleus perfusate cAMP decreased role. 4. 2 minutes before electroacupuncture, intravenous haloperidol 2 mg / kg can enhance the electroacupuncture analgesia, but 1 or 2 mg / kg of haloperidol in rabbit cauda equina after caudal cAMP decreased role No significant effect.