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目的 观察前列腺素E1脂微球载体制剂 (LipoPGE1)对糖尿病周围神经病变的治疗效果。方法6 4例糖尿病周围神经病变患者随机分为两组 ,治疗组给予LipoPGE1;对照组予以VitB1,疗程均为 14d。结果 治疗组治疗后周围神经症状明显减轻 ,运动神经传导速度 (MNCV)增快 (P <0 .0 1) ,而对照组治疗前后糖尿病周围神经症状、MNCV改变不明显 (P >0 .0 5 ) ,两组比较差异显著 (P <0 .0 5 )。结论 前列腺素E1脂微球载体制剂治疗糖尿病周围神经病变有一定的疗效。
Objective To observe the therapeutic effect of LipoPGE1 on diabetic peripheral neuropathy. Methods Sixty-four patients with diabetic peripheral neuropathy were randomly divided into two groups: the treatment group received LipoPGE1; the control group received VitB1 for 14 days. Results After treatment, the symptoms of peripheral nerves in the treatment group were significantly reduced and the motor nerve conduction velocity (MNCV) was increased (P <0.01). However, the changes of peripheral nerve in diabetic patients before and after treatment were not obvious (P> 0.05) ), The difference between the two groups was significant (P <0.05). Conclusion Prostaglandin E1 lipid microspheres carrier preparation for the treatment of diabetic peripheral neuropathy have a certain effect.