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目的:通过病例报道及文献复习提高对可逆性后部白质脑病综合征(RPLS)的认识。方法:报道1例硼替佐米联合地塞米松治疗多发性骨髓瘤过程中并发RPLS的临床特点及治疗过程,并进行文献复习。结果:RPLS是硼替佐米联合地塞米松治疗多发性骨髓瘤期间罕见的并发症。结论:多发性骨髓瘤患者在应用硼替佐米联合地塞米松治疗时应重视RPLS的高危因素,恰当治疗能使RPLS迅速好转。
OBJECTIVE: To raise awareness of reversible posterior white matter disease syndrome (RPLS) through case reports and literature review. Methods: One case of Bortezomib combined with dexamethasone in the treatment of multiple myeloma complicated with RPLS clinical features and course of treatment, and literature review. RESULTS: RPLS was a rare complication of bortezomib plus dexamethasone in the treatment of multiple myeloma. Conclusion: Patients with multiple myeloma should pay attention to the risk factors of RPLS when using bortezomib in combination with dexamethasone. Appropriate treatment can rapidly improve RPLS.