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目的:分析和研究自身免疫性肝炎患者的临床表现及其治疗,为有效诊治该疾病提供有价值的参考。方法:选取我院2010年1月-2013年1月收治的自身免疫性肝炎患者30例,对所有患者的临床资料进行回顾性分析。结果:本组自身免疫性肝炎患者均采用免疫抑制剂与激素进行综合治疗,30例患者中对该类药物治疗完全应答的患者有18例,部分应答有7例,持续缓解有5例,临床治疗效果显著。结论:自身免疫性肝炎患者以女性居多,临床症状不明显,多以I型为主,一般情况下,抗核抗体和抗平滑肌抗体呈阳性,但是抗线粒体抗体呈阴性,同时伴有肝外自身免疫性疾病。通过对患者的临床表现、肝脏病理情况、自身免疫性抗体检测以及肝外疾病等方面临床资料综合分析可以确诊,采用激素以及免疫抑制剂进行治疗,临床疗效显著,值得推广。
Objective: To analyze and study the clinical manifestation and treatment of patients with autoimmune hepatitis to provide a valuable reference for the effective diagnosis and treatment of the disease. Methods: Thirty patients with autoimmune hepatitis treated in our hospital from January 2010 to January 2013 were selected and the clinical data of all patients were retrospectively analyzed. Results: The patients with autoimmune hepatitis were treated with immunosuppressive agents and hormones. Among 30 patients, 18 patients responded completely to these drugs, 7 patients responded partially, 5 patients sustained remission, The treatment effect is remarkable. Conclusion: The majority of patients with autoimmune hepatitis are mostly female, but their clinical symptoms are not obvious. Most of them are type I. In general, anti-nuclear antibodies and anti-smooth muscle antibodies are positive, but anti-mitochondrial antibodies are negative, accompanied by extrahepatic Immune disease. Through the clinical manifestations of patients, liver pathology, autoimmune antibody testing and extrahepatic diseases and other aspects of clinical data can be confirmed by comprehensive analysis of the use of hormones and immunosuppressive agents for treatment, the clinical efficacy is significant and worth promoting.