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目的 :探讨传染性非典型肺炎 (IAP)的流行病学、临床特点、病原学检查及预后。方法 :根据中国卫生部IAP临床诊断标准。采用间接免疫荧光法检测抗冠状病毒IgG。分析本组 (8例 )病例特点 ,患者均有密切接触史 ,潜伏期 1～10天 ;均发热 ,且热型多不规则。胸片特点 :本组肺部均出现片状或斑片状炎症阴影。常规予广谱抗生素、利巴韦林抗病毒以及免疫球蛋白、生物反应调节剂胸腺肽等治疗无效 ,予甲基强的松龙治疗有效。结果 :本组均符合IAP临床诊断标准。 7例存活者于半个月～ 2个月内肺部炎症阴影均完全吸收。 1例死于呼吸衰竭。住院时间 14～ 4 4天 ,平均 (2 8 9± 13 7)天。 3例抗冠状病毒IgG阳性 ,且恢复期的抗体滴度比急性期增高 4倍以上。结论 :IAP是一种传染性极强的疾病。本组以近距离传播为主 ,具有家族局部爆发流行的特点。以发热为主要表现 ,热程多在 14天左右 ,重症者可长达 30多天。该疾病侵犯多个肺叶 ,及肺部以外的其他器官。激素可以促使肺部炎症的吸收。病原体是冠状病毒
Objective: To investigate the epidemiology, clinical features, etiological examination and prognosis of SARS. Methods: According to the Chinese Ministry of Health IAP clinical diagnostic criteria. Anti-Coronavirus IgG was detected by indirect immunofluorescence assay. Analysis of the characteristics of the group (8 cases), patients have close contact history, the incubation period of 1 to 10 days; are fever, and more irregular heat. Chest radiograph Features: This group of lungs are patchy or patchy inflammation of the shadow. Conventional broad-spectrum antibiotics, ribavirin antiviral and immunoglobulin, biological response modifier thymosin treatment ineffective, methylprednisolone treatment effective. Results: All patients were in accordance with IAP clinical diagnostic criteria. Seven cases of survivors within half a month to 2 months the shadow of lung inflammation were completely absorbed. One patient died of respiratory failure. The length of hospital stay was 14 to 44 days, with an average of (2 8 9 ± 13 7) days. 3 cases of anti-coronavirus IgG positive, and recovery of antibody titers increased more than 4 times the acute phase. Conclusion: IAP is a highly contagious disease. This group is mainly based on short-range transmission, with a family of local outbreaks of the popular features. To fever as the main performance, heat more than 14 days, severe cases can be as long as 30 days. The disease affects multiple lobes and other organs outside the lungs. Hormone can promote the absorption of lung inflammation. The pathogen is a coronavirus