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目的观察比索洛尔联合氯沙坦治疗高血压对患者左室舒张功能的影响。方法40例高血压患者(1级22例,2级18例)使用比索洛尔5 mg和氯沙坦50 mg,连服6个月,不改变用药量,并于治疗前后用M超和二维超声测定左室舒张功能。结果治疗6个月,血压由(169±6)/(99±7)mm Hg(1mm Hg=0.133kPa),降到(113±7)/(74±9)mm Hg,治疗后左室舒张功能的左室舒张早期流速峰值(PE)和舒张早期流速积分(SE)明显增高。舒张晚期流速峰值(PA)明显降低,虽舒张晚期流速积分(SA)有降低,但差异无统计学意义。PA/PE由0.81±0.12降到0.56±0.25(P<0.01)。结论比索洛尔、氯沙坦联合治疗对左室舒张功能改善明显。
Objective To observe the effect of bisoprolol plus losartan on left ventricular diastolic function in patients with hypertension. Methods Forty hypertensive patients (22 in grade 1 and 18 in grade 2) were treated with bisoprolol 5 mg and losartan 50 mg for 6 months without change of dosage. Before and after treatment, Dimensional ultrasound measured left ventricular diastolic function. Results The blood pressure decreased from (169 ± 6) / (99 ± 7) mm Hg (1 mm Hg = 0.133 kPa) to (113 ± 7) / (74 ± 9) mm Hg after 6 months of treatment. Function of early left ventricular diastolic velocity peak (PE) and early diastolic velocity integral (SE) was significantly higher. The peak value of late diastolic velocity (PA) was significantly lower, although the late diastolic velocity integral (SA) decreased, but the difference was not statistically significant. PA / PE decreased from 0.81 ± 0.12 to 0.56 ± 0.25 (P <0.01). Conclusion Bisoprolol and losartan combination therapy can improve left ventricular diastolic function.