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目的检测妊高征胎盘的Fas蛋白表达水平,探讨妊高征的发病机制。方法采用免疫组织化学方法结合病理图像分析技术,定量分析10例正常妊娠组与30例妊高征组胎盘Fas蛋白表达。结果Fas蛋白主要表达与胎盘绒毛滋养细胞的胞膜及胞浆内。与正常妊娠组比较,妊高征组胎盘Fas蛋白表达显著增加,轻度、中度、重度妊高征组比较,有显著性差异。结论胎盘滋养层细胞Fas蛋白表达增加可能是妊高征的发病机制之一,从而为临床治疗妊高征提供新的方向。
Objective To detect the expression of Fas protein in placenta of pregnancy induced hypertension and to explore the pathogenesis of PIH. Methods Immunohistochemistry and pathological image analysis techniques were used to quantitatively analyze the placenta Fas protein expression in 10 normal pregnant women and 30 pregnant women with pregnancy induced hypertension. Results Fas protein was mainly expressed in the membrane and cytoplasm of placental villous trophoblast cells. Compared with the normal pregnancy group, placental expression of Fas protein increased significantly in PIH group, and there was significant difference in mild, moderate and severe PIH group. Conclusion The increased expression of Fas protein in placental trophoblastic cells may be one of the pathogenesis of PIH, which may provide a new direction for the clinical treatment of PIH.