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目的 探讨CyclinD1,P16在胶质瘤复发前后表达改变及其意义。方法 采用免疫组织化学LsABC法对 4 5例复发胶质瘤瘤组织、瘤旁脑组织和 10例正常脑组织CyclinD1,P16蛋白表达进行检测 ,统计分析CyclinD1,P16表达水平与胶质瘤分级、肿瘤复发的关系。结果 正常脑组织 ,瘤旁脑组织和胶质瘤组织CyclinD1表达依次升高 ,而P16的表达依次下降 ;肿瘤复发CyclinD1表达增强 ,P16的表达减弱。结论 CyclinD1与P16的表达与胶质瘤恶性进程和复发密切相关。
Objective To investigate the changes of CyclinD1 and P16 in glioma before and after recurrence and its significance. Methods Immunohistochemical LsABC method was used to detect the expression of CyclinD1 and P16 protein in 45 recurrent glioma tissues, para-tumorous brain tissues and 10 normal brain tissues. The expressions of CyclinD1 and P16 in glioma tissues, tumor grade Relapse relationship. Results The expression of CyclinD1 in normal brain tissue, para-tumorous brain tissue and glioma increased in turn, while the expression of P16 decreased in turn. The expression of CyclinD1 increased and the expression of P16 decreased in tumor recurrence. Conclusion The expressions of CyclinD1 and P16 are closely related to the malignant progression and recurrence of glioma.