别名婴幼儿持续性高胰岛素血症(Persistent hyperinsulinemic hypoglycemia of infancy,PHHI)家族性高胰岛素血症;青少年起病型糖尿病(MOPY);胰岛细胞发育不良症自1981年Aynsley-Gren等首次报道PHHI以来~[1],后续学者对其遗传背景做了大量和深入的研究,清楚一些,还有相当一些还不算清楚。PHHI至今还是一种极少见的遗传性疾病,使胰岛β细胞持续不适当分泌胰岛素是PHHI的病理生理基础。在少见中而又以近亲结婚的沙特阿拉伯 Alias ​​Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) familial hyperinsulinemia; juvenile onset diabetes mellitus (MOPY); islet cell dysplasia Since Aynsley-Gren first reported PHHI in 1981 ~ [1], follow-up scholars have done a lot of and in-depth study of their genetic background, clearly some, there are quite a few not yet clear. PHHI is still a rare genetic disease to date, and the continued inappropriate secretion of pancreatic β-cells is the pathophysiology of PHHI. Saudi Arabia, a rare but married relative