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作者对心肌梗塞后伴轻度运动耐量降低的病人口服伊那普利(enalapril)一年以上,并利用心肺运动试验来观察其作用。方法和结果共有160例男性心肌梗塞病人且其高峰氧耗量(PVO_2)小于25ml/kg/min者作为研究对象。所有病人心功能分级(NYHA)均为1～2级。病人分为二组:第一组为心肌梗塞后21天,共100例,平均年龄 60.3±7.6岁,随机分为二亚组,口服伊那普利 20mg/d或安慰剂。第二组为心肌梗塞后 6个月,共 60例,平均年龄 62.4± 7.3岁,也随机分成口服伊那普利 20mg/d或安慰剂二亚组。病人允许继续服用噻吗洛尔或必要时服抗心律失常药物。病人在第4,8,12,24,36和48周时作心
The authors orally administered enalapril for more than a year to patients with post-MI with mild exercise tolerance and observed their effects using cardiopulmonary exercise tests. Methods and Results A total of 160 male patients with myocardial infarction and their peak oxygen consumption (PVO_2) of less than 25ml / kg / min were studied. All patients with NYHA were grade 1 to 2. Patients were divided into two groups: the first group was 21 days after myocardial infarction, a total of 100 cases, the average age of 60.3 ± 7.6 years, were randomly divided into two subgroups, oral enalapril 20mg / d or placebo. The second group was 6 months after myocardial infarction with a total of 60 patients with an average age of 62.4 ± 7.3 years and were also randomized to either oral or randomized, placebo, or sub-enalapril 20 mg / day. Patients are allowed to continue taking timolol or, if necessary, take anti-arrhythmic drugs. The patient became mentally active at weeks 4, 8, 12, 24, 36 and 48