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目的:本研究的目的是评估以左氧氟沙星为基础的三联疗法根除幽门螺杆菌的疗效分析。方法:112例通过快速尿素酶试验和13C-尿素呼气试验证实感染了幽门螺杆菌的非溃疡性消化不良的患者入组本实验,患者被随机分为7d组(54例)和14d组(58例),接受包括雷贝拉唑(10mgb.i.d.)加左氧氟沙星(500mgq.d.)和阿莫西林(1000mgb.i.d.)的治疗,并进行6周的随访,治疗结束至少4周后通过13C-尿素呼气试验确定根除率。结果:幽门螺杆菌总的根除率为83.9%(ITT)和88.7%(PP)。7d组51名患者完成了治疗,其根除率为75.9%(ITT)、80.4%(PP),而14d组的根除率达到91.4%(ITT)、96.4%(PP),P<0.05。结论:包含雷贝拉唑、左氧氟沙星和阿莫西林的三联疗法对于根除幽门螺杆菌是有效的,但相同方案的14d疗法疗效明显优于7d疗法。
Purpose: The purpose of this study was to evaluate the efficacy of levofloxacin-based triple therapy in the eradication of Helicobacter pylori. Methods: One hundred and twelve patients with non-ulcer dyspepsia confirmed by rapid urease test and 13C-urea breath test were enrolled in this study. Patients were randomly divided into 7d group (54 cases) and 14d group 58) received treatment with rabeprazole (10 mg b.id) plus levofloxacin (500 mgq.d.) And amoxicillin (1000 mg b.id) for 6 weeks followed by at least 4 weeks after the end of treatment Urea breath test to determine eradication rate. Results: The total eradication rates of Helicobacter pylori were 83.9% (ITT) and 88.7% (PP). In the 7d group of 51 patients, the eradication rate was 75.9% (ITT) and 80.4% (PP), while the eradication rate was 91.4% (ITT) and 96.4% (PP) in the 14d group, P <0.05. CONCLUSION: Triple therapy with rabeprazole, levofloxacin and amoxicillin is effective in eradicating H. pylori, but the 14d therapy with the same regimen is significantly better than the 7d regimen.