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帕金森病是一种常见的神经系统退行性疾病,主要是由黑质多巴胺能神经元变性引起。其临床表现可分为运动症状和非运动症状。运动症状是目前帕金森病治疗的重点,但随着对该病认识的深入,非运动症状越来越引起广大医生的关注。体重下降是帕金森病非运动症状之一。帕金森病患者体重下降的发生可能和机体能量代谢失衡?疾病本身?吞咽困难?药物治疗?嗅觉下降?痴呆?瘦素?性别等因素有关。下丘脑广泛的神经元变性可能是导致体重下降的原因。本文就影响PD患者体重改变的有关因素及其可能机制进行综述。
Parkinson’s disease is a common degenerative disease of the nervous system, mainly caused by degeneration of nigral dopaminergic neurons. Its clinical manifestations can be divided into motor symptoms and non-motor symptoms. Motor symptoms are the focus of the current treatment of Parkinson’s disease, but with the understanding of the disease in-depth, non-motor symptoms more and more aroused the attention of the majority of doctors. Weight loss is one of the non-motor symptoms of Parkinson’s disease. The incidence of weight loss in Parkinson’s disease may be related to the imbalance of energy metabolism, the disease itself, dysphagia, drug treatment, decreased smell, dementia, leptin, gender and other factors. Extensive neuronal degeneration in the hypothalamus may be the cause of weight loss. This article reviews the factors that affect the weight changes in PD patients and their possible mechanisms.