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目的探讨反流性食管炎食管外表现与酸反流的关系。方法研究对象为2006年1月至2007年2月在卫生部北京医院消化科、呼吸科及耳鼻喉科门诊和住院的患者,均经胃镜检查证实为反流性食管炎(RE),具有烧心、反酸等胃食管反流和(或)RE的食管外症状(咳嗽、咽喉痛、咽部异物感、声音嘶哑等)。依据患者的主要症状分为食管外表现组及对照组(不具有食管外表现)。食管外表现组32例,对照组35例。所有患者在治疗前均进行24 h食管pH监测,并于治疗前、后对症状积分评定。所有患者均给予质子泵抑制剂(PPI)治疗。结果食管外表现组与对照组PPI治疗的有效率分别为86.4%与91.7%,差异无统计学意义(P>0.05)。结论反流性食管炎的食管外症状与酸反流显著相关。
Objective To investigate the relationship between esophageal reflux and acid reflux in patients with reflux esophagitis. Methods Patients from January 2006 to February 2007 in Department of Gastroenterology, Respiratory and Otorhinolaryngology Clinic and Hospitalization of Beijing Hospital of Ministry of Health, all confirmed by gastroscopy as reflux esophagitis (RE), with heartburn , Reflux of acid and other gastroesophageal reflux and / or extra-esophageal symptoms of RE (cough, sore throat, foreign body sensation in throat, hoarseness, etc.). According to the main symptoms of patients divided into external esophageal presentation group and control group (without esophageal appearance). Esophageal manifestations group of 32 patients, control group of 35 patients. All patients underwent 24 h esophageal pH monitoring before treatment and symptom scores were assessed before and after treatment. All patients were treated with proton pump inhibitor (PPI). Results The effective rates of PPI treatment in esophageal and control groups were 86.4% and 91.7% respectively, with no significant difference (P> 0.05). Conclusions Esophageal reflux symptoms are associated with acid reflux.