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目的探讨辛伐他汀在治疗老年慢性肾功能衰竭(慢性肾衰)时,在改善炎症反应及血脂代谢中的应用。方法 77例慢性肾衰患者,入院后均给予常规慢性肾衰对症治疗,同时给予服用辛伐他汀治疗。观察炎性因子及血脂水平变化情况。结果患者治疗后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及单核细胞超化蛋白-1(MCP-1)、C反应蛋白(CRP)水平均较治疗前有明显改善,差异有统计学意义(P<0.05)。结论辛伐他汀治疗老年慢性肾衰,可有效降低炎性因子水平,减轻炎症反应,具有明显的抗炎作用。同时,辛伐他汀还可改善脂质代谢物水平,这对于改善患者临床症状,减少高脂血症等的发生具有重要意义。
Objective To investigate the use of simvastatin in the treatment of elderly patients with chronic renal failure (chronic renal failure) and to improve the inflammatory response and blood lipid metabolism. Methods 77 cases of chronic renal failure patients were admitted to the hospital after the conventional chronic renal failure symptomatic treatment, given Simvastatin treatment. Observe the changes of inflammatory factors and blood lipid levels. Results After treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and monocyte- -1), C-reactive protein (CRP) levels were significantly improved than before treatment, the difference was statistically significant (P <0.05). Conclusion Simvastatin treatment of senile chronic renal failure, can effectively reduce the level of inflammatory cytokines, reduce inflammation, with obvious anti-inflammatory effect. At the same time, simvastatin can also improve the level of lipid metabolites, which is important for improving the clinical symptoms of patients and reducing the incidence of hyperlipidemia.