Qikou sag, located in north-center of Huanghua depression in Bohai Basin, is a Cenozoic sag with rich hydrocarbon. As a microcosm of Bohai Basin, the fault characteristics of Cenozoic structural layers in Qikou sag could indicate and record the evolution of Cenozoic stress field in Bohai Basin. Based on the latest 3-D seismic data, the study takes statistics on the fault system of Cenozoic structural layers and analyzes the fault throws of major large faults along the strikes in different periods in Qikou sag, then the fault distribution regularities and the fault direction characteristics in each structural layer are summarized. The result shows that during Cenozoic, the fault activity strength migrates from southwest to northeast and the strikes of faults changes from northwestward in Sha-3 period to nearly east-westward since Sha-1 period. Qikou sag, located in north-center of Huanghua depression in Bohai Basin, is a Cenozoic sag with rich hydrocarbon. As a microcosm of Bohai Basin, the fault characteristics of Cenozoic structural layers in Qikou sag could indicate and record the evolution of Cenozoic stress field in Bohai Basin. Based on the latest 3-D seismic data, the study takes statistics on the fault system of Cenozoic structural layers and analyzes the fault throws of major large faults along the strikes in different periods in Qikou sag, then the fault distribution regularities and the fault direction characteristics in each structural layer are summarized. The result shows that during Cenozoic, the fault activity strength migrates from southwest to northeast and the strikes of faults changes from northwestward in Sha-3 period to nearly east-westward since Sha-1 period.