目的　研究血清胆碱酯酶、白蛋白及血浆凝血酶原活动度与病毒性肝炎肝组织病理损害的关系。方法　采用酶速率法 ,测定 135例经病理证实的慢性肝炎、肝炎肝硬化及重型肝炎患者的血清胆碱酯酶活动力及白蛋白 ,同时采用比浊法测定他们的血浆凝血酶原活动度。结果　在慢性肝炎轻度至中度 ,血清胆碱酯酶活力较白蛋白及血浆凝血酶原活动度下降的百分率更高 ,差异有非常显著性意义 ,P均 <0 0 1;随着肝组织炎症程度的加重 ,各项指标均逐渐下降 ,差异有非常显著性意义 ,P均 <0 0 0 1;随着肝组织纤维化程度的加重 ,各项指标均逐渐下降 ,差异有非常显著性意义 ,P均 <0 0 0 1;血清胆碱酯酶活力、白蛋白及血浆凝血酶原活动度彼此间相关系数为 0 72 0～ 0 778(P均 <0 0 0 1)。结论　血清胆碱酯酶活力较白蛋白及血浆凝血酶原活动度能更好地反映肝脏的合成功能和储备功能 ,能更准确地反映肝脏的病理损害程度 ,它们均与肝脏的病理损害呈明显的负相关 Objective To study the relationship between serum cholinesterase, albumin, prothrombin activity and hepatic histopathological damage in viral hepatitis. Methods Serum cholinesterase activity and albumin in 135 patients with pathologically confirmed chronic hepatitis, cirrhosis of liver and severe hepatitis were measured by enzymatic rate method, and their plasma prothrombin activity was measured by turbidimetry. The results in mild to moderate chronic hepatitis, serum cholinesterase activity than albumin and plasma prothrombin activity decreased more significantly, the difference was significant (P <0.01); with the liver tissue The degree of inflammation was aggravated, and all the indexes were gradually decreased, the difference was significant (P <0.01). With the aggravation of liver fibrosis, the indexes decreased gradually, the difference was significant , All P <0 0 01. The correlation coefficients of serum cholinesterase activity, albumin and plasma prothrombin activity were 0 72 0 ~ 0 778 (all P 0 01). Conclusions The activity of serum cholinesterase is better than that of albumin and prothrombin to reflect the synthesis and reserve functions of liver, which can reflect the degree of pathological damage of liver more accurately. All of them have obvious pathological damage with liver The negative correlation