论文部分内容阅读
目的比较并探究奥曲肽联合不同剂量垂体后叶素治疗血吸虫性肝硬化继发上消化道出血的应用研究。方法106例消化科住院并进行治疗的血吸虫性肝硬化继发性上消化道出血的患者,随机分为对照组和观察组,各53例。对照组患者使用奥曲肽0.05mg/ml进行前期静脉推注,保持25μg/h维持静脉滴注的效果,保持0.5ml/min进行维持治疗。观察组患者奥曲肽联合垂体后叶素1U/ml静脉滴注0.5h左右,保持0.5ml/min进行维持治疗。比较两组患者的临床效果、止血效果以及不良反应发生的情况。结果两组患者总有效率比较差异无统计学意义(P>0.05);两组的平均止血时间和止血量比较差异均无统计学意义(P>0.05);观察组的不良反应发生率明显小于对照组(P<0.05)。结论奥曲肽联合小剂量垂体后叶素治疗血吸虫性肝硬化继发上消化道出血不良反应较少,用药量较少,可在临床上进一步推广运用。
Objective To compare and explore the application of octreotide combined with different doses of vasopressin in the treatment of schistosomiasis cirrhosis secondary to upper gastrointestinal bleeding. Methods A total of 106 patients with gastrointestinal bleeding who were hospitalized and treated for schistosome-induced cirrhosis were randomly divided into control group and observation group, with 53 cases in each group. Patients in the control group were given intravenous injection of octreotide 0.05 mg / ml to maintain the effect of intravenous drip at 25 μg / h and maintenance treatment at 0.5 ml / min. Observed patients with octreotide combined pituitrin 1U / ml intravenous infusion of 0.5h or so, maintaining 0.5ml / min for maintenance treatment. The clinical effects, hemostatic effects and adverse reactions of the two groups were compared. Results There was no significant difference in the total effective rate between the two groups (P> 0.05). There was no significant difference between the two groups in mean hemostasis time and hemostatic volume (P> 0.05). The incidence of adverse reactions in the observation group was significantly less than Control group (P <0.05). Conclusion Octreotide combined with low dose of pituitrin treatment of schistosomiasis cirrhosis secondary to upper gastrointestinal bleeding less adverse reactions, the amount of medication less can be further promoted in clinical use.