骨肉瘤(osteosarcoma)是一种高侵袭性骨肿瘤,好发于儿童和青少年。骨肉瘤的发生是多基因、多步骤的复杂过程,已证明与抑癌基因异常表达有一定的相关性。抑癌基因异常表达有两大机制:遗传学(ge netic)层面,即通过DNA核酸序列改变而形成突变,包括基因缺失、基因突变和基因重排等; Osteosarcoma is a highly aggressive bone tumor that occurs in children and adolescents. The occurrence of osteosarcoma is a multi-gene, multi-step complex process that has been shown to have some correlation with the abnormal expression of tumor suppressor genes. There are two mechanisms of abnormal expression of tumor suppressor genes: ge netic level, that is, mutations are formed through DNA nucleic acid sequence changes, including gene deletion, gene mutation and gene rearrangement;