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目的 建立胰岛素抵抗基础上的局灶性脑缺血模型 ,观察通脑精胶囊对模型大鼠神经功能缺损及胰岛素抵抗的影响。方法 通过高糖饲料喂养复制胰岛素抵抗 (IR)大鼠模型 ,在此基础上采用电凝大脑中动脉造成局灶性脑缺血 ,观察通脑精胶囊对各组神经功能缺损积分、血糖、血清胰岛素 (Ins)、胰岛素抗体 (InsAb)、胰岛素敏感指数 (ISI)等指标的变化。结果 高糖饲料喂服 4周时 ,部分大鼠即自发地出现不同程度的神经功能缺损症状 ;大鼠局灶性脑缺血后 2周血清Ins水平显著升高 (P <0 0 1) ,血糖也明显升高 (P <0 0 1) ,ISI明显降低 (P <0 0 1) ,C肽水平降低而InsAb显著升高 (P <0 0 1) ;经通脑精胶囊治疗后 ,上述指标均有不同程度的好转 (P <0 0 1)。结论 IR既作为可能的独立危险因素引起局灶性脑缺血的发生 ,又作为脑缺血的病理产物参与其发病后的整个病理生理过程 ,而中药通脑精胶囊具有逆转IR作用 ,并可能通过改善IR而减轻缺血性脑组织损伤 ,恢复神经功能缺损
Objective To establish a model of focal cerebral ischemia based on insulin resistance and observe the effects of Tongnaojing Capsule on neurological deficit and insulin resistance in model rats. Methods The rat model of insulin resistance (IR) was fed by high-sugar diet. Based on this, the middle cerebral artery was used to induce focal cerebral ischemia. The neurological deficits, blood glucose, serum of Tongnaojing capsules were observed. Insulin (Ins), insulin antibody (InsAb), insulin sensitivity index (ISI) and other indicators of change. Results When high sugar diets were fed for 4 weeks, some rats spontaneously showed symptoms of neurological deficits. The serum Ins levels increased significantly after 2 weeks of focal cerebral ischemia (P < 0.01). Blood glucose also increased significantly (P <0 01), ISI significantly decreased (P <0 01), C-peptide levels decreased, and InsAb increased significantly (P <0 01); after treatment with Tongnaojing Capsule, the above The indicators have improved to varying degrees (P < 0 01). Conclusion IR is not only a possible independent risk factor to cause focal cerebral ischemia, but also as a pathological product of cerebral ischemia to participate in the whole pathophysiological process after its onset. The traditional Chinese medicine Tongnaojing Capsule has the effect of reversing IR and may Reduces ischemic brain tissue damage and restores neurological deficits by improving IR