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抗肿瘤药物除用于治疗肿瘤外,还常作为免疫抑制剂广泛用于临床。对某些类型的肿瘤,常同时或序贯并用抗肿瘤药、辅助治疗药,以提高抗肿瘤作用,降低毒性反应和耐药性的产生。药物联用有可能增效,但也有可能因药物相互作用,而致副作用的发生率增加,甚至有时因配伍不当引起毒性反应。抗肿瘤药物副作用较大,且有些药物安全范围又狭窄。因此临床上合并用药时对其药物相互作用应引起注意。现仅就几种常用抗肿瘤药物与它药并用时产生的相互作用简介如下,以供参考。一、环磷酰胺(CPM)与下列各药并用时的作用 1.氯霉素:能明显地减弱CPM的作用和毒性。这种作用是由于在体内使CPM活化的微粒体酶
In addition to the use of anti-cancer drugs for the treatment of tumors, they are often used as immunosuppressive agents in clinical practice. For some types of tumors, often simultaneously or sequentially and with anti-tumor drugs, adjuvant drugs to enhance anti-tumor effect, reduce toxicity and drug resistance. Drugs may synergize, but may also be due to drug interactions, which led to an increased incidence of side effects, and sometimes even due to improper compatibility caused by toxic reactions. Side effects of antineoplastic drugs larger, and some drug safety range and narrow. Therefore, the clinical drug combination should pay attention to its drug interactions. Now only several commonly used antitumor drugs and its use when the interaction generated when the following is for reference. First, cyclophosphamide (CPM) and the role of the following drugs: 1. Chloramphenicol: CPM can significantly reduce the role and toxicity. This effect is due to the microsomal enzymes that activate CPM in the body