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动力性消化不良是很常见的消化系统疾病,其发病机理尚不明确,病人胃排空减慢。临床上可用抗酸药、H_2受体拮抗剂和胃动力剂等治疗。 Sulpiride具有对抗中心性和周围性多巴胺活性的作用,广泛地用于精神病的治疗。以往研究表明,此药的药理活性主要与其左旋结构有关,左旋结构在50％以下的剂量比消旋结构有活性且副作用小。Levosulpiride具有调节上消化道运动神经的作用。domper-idone对胃食道返流症及动力性消化不良有确切的疗效。作者采用随机双盲法对40例患有功能性消化不良的病人进行研究,levosulpiride每日剂量75mg,domperidone每日剂量60
Motility dyspepsia is a very common digestive system disease, the pathogenesis is not clear, patients with gastric emptying slowed down. Clinically available antacids, H 2 receptor antagonists and gastric motility agents and other treatment. Sulpiride has the effect of counteracting central and peripheral dopamine activity and is widely used in the treatment of psychosis. Previous studies have shown that the pharmacological activity of this drug is mainly related to its left-handed structure, the dose of less than 50% of the left-handed structure is more active than the racemic structure with little side effects. Levosulpiride regulates the upper gastrointestinal motor nerve. Domper-idone on gastroesophageal reflux disease and dynamic dyspepsia have the exact effect. The authors used a randomized double-blind study of 40 patients with functional dyspepsia, with a daily dose of levosulpiride 75 mg and a daily dose of domperidone 60