论文部分内容阅读
目的:探讨磁共振弥散加权成像(diffusion weighted imaging,DWI)在鼻咽癌调强放疗、放疗后随访的临床价值。方法:分析经病理证实的32例鼻咽癌患者在放疗前、放疗剂量40 Gy时和放疗结束后均行MRI常规扫描、增强扫描及DWI检查,分析病变体积及弥散表观系数(apparent diffusion coefficient,ADC)值动态变化情况,并探讨两者的相关性。结果:随着调强放疗时间的延长,肿瘤体积不同程度缩小,且不同放疗时间段各组间差异具有统计学意义(P<0.05);ADC值逐渐增高,放疗晚期ADC的增高程度大于放疗早期的增高程度,且不同放疗时间段各组间差异具有统计学意义(P<0.05);肿瘤体积与ADC值呈负相关(r=-0.667,P=0.000)。结论:MRI及DWI-MRI成像可较准确的显示鼻咽癌调强放疗后形态学、组织学变化,能较好的监测NPC放射治疗后肿瘤的消退情况和治疗的敏感性。
Objective: To investigate the clinical value of diffusion weighted imaging (DWI) in metastatic nasopharyngeal carcinoma after radiation therapy and radiotherapy. Methods: Thirty-two patients with nasopharyngeal carcinoma confirmed by pathology underwent conventional MRI, enhanced scan and DWI before radiotherapy, 40 Gy and at the end of radiotherapy. The volume of lesions and apparent diffusion coefficient , ADC) dynamic changes, and explore the correlation between the two. Results: With the extension of intensity-modulated radiation therapy, the volume of tumor decreased to different extents, and the difference between different groups was statistically significant (P <0.05); the ADC value increased gradually and the increase of advanced radiotherapy was more than that of early radiotherapy (P <0.05). There was a negative correlation between tumor volume and ADC value (r = -0.667, P = 0.000). Conclusion: MRI and DWI-MRI imaging can accurately show the morphological and histological changes of NPC after IMRT, and can better monitor the regression and treatment sensitivity of NPC after radiotherapy.