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目的探讨不同剂量阿托伐他汀钙片在不稳定型心绞痛患者经皮冠状动脉介入治疗(PCI)中的效果。方法选取2012年1月至2014年6月在吉林省人民医院行PCI手术的176例不稳定型心绞痛患者作为研究对象,按随机数字表法将其分为观察组和对照组,各88例。对照组患者晚间顿服阿托伐他汀钙片20 mg,观察组患者晚间顿服阿托伐他汀钙片40 mg,比较两组患者术前12 h、术后24 h、2周的C反应蛋白(CRP)、心肌肌钙蛋白Ⅰ(c TnⅠ)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及心脏不良事件(MACE)的发生情况。结果术后2周,观察组患者的CRP、c TnⅠ水平均明显高于对照组,TC、TG、LDL-C、HDL-C水平均明显低于对照组,差异均有统计学意义(均P<0.05)。结论不稳定型心绞痛患者PCI术前和术后服用大剂量(40 mg)阿托伐他汀钙片可有效降低术后炎性反应,稳定粥样斑块,减少MACE的发生。
Objective To investigate the effect of different doses of atorvastatin calcium tablets in percutaneous coronary intervention (PCI) in patients with unstable angina pectoris. Methods A total of 176 patients with unstable angina pectoris undergoing PCI at Jilin Provincial People’s Hospital from January 2012 to June 2014 were selected as study subjects and divided into observation group and control group according to random number table method, with 88 cases in each group. Patients in the control group received 20 mg of atorvastatin calcium overnight and 40 mg of atorvastatin calcium in the evening meal in the observation group. The levels of C-reactive protein (CRP), cTnⅠ, TC, TG, LDL-C and HDL-C, Cardiac adverse events (MACE) of the situation. Results The levels of CRP and cTnⅠ in the observation group were significantly higher than those in the control group at 2 weeks after operation. The levels of TC, TG, LDL-C and HDL-C in the observation group were significantly lower than those in the control group (all P <0.05). Conclusions Patients with unstable angina pectoris taking high dose (40 mg) of atorvastatin calcium before and after PCI can effectively reduce postoperative inflammatory reaction, stabilize atherosclerotic plaque and reduce the occurrence of MACE.