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目的探讨替莫唑胺联合同步放疗治疗脑转移瘤患者的临床效果。方法选取2013年1月至2015年1月佛山市顺德区中医院收治的50例脑转移瘤患者作为研究对象,按随机数字表法将其分为观察组与对照组,各25例。对照组患者单纯实施放疗,观察组患者在对照组基础上口服替莫唑胺,比较两组患者的临床疗效、不良反应发生情况、复发时间与中位生存期。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者的复发时间与中位生存期均明显长于对照组,差异均有统计学意义(均P<0.05)。结论对脑转移瘤患者实施替莫唑胺联合同步放疗治疗临床效果明显,能延长患者的复发时间与中位生存期。
Objective To investigate the clinical effect of temozolomide combined with concurrent radiotherapy in patients with brain metastases. Methods From January 2013 to January 2015, 50 patients with brain metastases treated by Shunde District Hospital of Traditional Chinese Medicine in Foshan City were selected as study subjects, and divided into observation group and control group according to random number table method, with 25 cases in each group. Patients in the control group were treated with radiotherapy alone. Patients in the observation group were given oral temozolomide on the basis of the control group. The clinical efficacy, incidence of adverse reactions, recurrence time and median survival time were compared between the two groups. Results The total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P <0.05). The recurrence time and median survival time of observation group were significantly longer than that of control group (P <0.05) All P <0.05). Conclusion The clinical effect of temozolomide combined with concurrent radiotherapy in patients with brain metastases is obvious, which can prolong the recurrence time and the median survival time.