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对肺结核病患者使用强抗结核药物引起假性恶化现象21例进行分析。其X线主要改变为:(1)上纵隔及肺门淋巴结肿大,(2)原发病灶周围出现新的渗出病灶,(3)渗出性胸膜炎。本组19例未改变原化疗方案治愈,其中15例加用免疫抑制剂治愈;另2例因肝功异常用INH+RFP完成疗程获愈。分析认为:杀菌药物在短期内杀死大量结核菌使其菌体蛋白、磷脂等短期入血,可引起全身特别是肺及淋巴结产生变态反应。
21 cases of pulmonary tuberculosis patients using strong anti-TB drugs cause false deterioration. The main changes to the X-ray: (1) the mediastinum and hilar lymph nodes, (2) the primary lesions around the emergence of new exudative lesions, (3) exudative pleurisy. The group of 19 patients did not change the original chemotherapy regimen, of which 15 cases were treated with immunosuppressive therapy; the other 2 cases of liver function abnormalities with INH + RFP to complete the course of treatment more. Analysis shows that: bactericidal drugs kill a large number of tuberculosis in the short term bacterial cell protein, phospholipids and other short-term blood, can cause systemic, especially the lungs and lymph nodes produce allergies.