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[目的]本项研究旨在观察黄芪提取波对自然衰老小鼠皮肤中ATP酶活力的影响,检测黄芪提取液在延缓小鼠皮肤自然衰老方面的作用。[方法]昆明种4月龄雌性小鼠12只作为青年对照组(A),18月龄雌性小鼠36只作为老年组,再随机分为3组,每组12只:老年空白对照组(B),老年阳性对照组(C),黄芪组(D)。用药30天,第31天处死动物并取材。[结果]与老年空白对照组(B)相比,黄芪组(D)小鼠皮肤组织中的ATP酶活力均明显升高(P<0.01)。[结论]中药黄芪提取液可以有效增加ATP酶的活性,达到延缓皮肤组织衰老的作用。
[Objective] The aim of this study was to observe the effects of Astragalus extract on the ATPase activity in the skin of naturally aged mice and to detect the effect of astragalus extract on delaying the natural aging of mice skin. [Method] Twelve female Kunming 4-month-old mice were used as the young control group (A) and 18-month-old female mice as the old group. They were randomly divided into three groups of 12 rats each: aged control group B), aged positive control group (C), Astragalus group (D). After 30 days of treatment, the animals were sacrificed and drawn on the 31st day. [Results] The ATPase activity in the skin tissue of Astragalus membranaceus group (D) was significantly higher than that of the aged blank control group (B) (P <0.01). [Conclusion] Astragalus extract of traditional Chinese medicine can effectively increase the activity of ATPase and delay the skin aging.