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目的观察纳洛酮分别联合更昔洛韦与病毒唑治疗小儿病毒性脑炎的疗效及对血清白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)水平的影响。方法将病毒性脑炎患儿120例随机分为试验组和对照组各60例,给予所有患儿常规治疗和护理,试验组给予纳洛酮联合更昔洛韦治疗,对照组给予纳洛酮联合病毒唑治疗,治疗1周后评价2组患儿治疗效果,并于治疗前后抽取2组患儿静脉血,检测并评价血清IL-1、TNF-α水平变化。结果试验组患儿治疗总有效率为93.33%高于对照组的76.67%;治疗后2组患儿血清IL-1、TNF-α水平均呈下降趋势,但试验组降幅大于对照组,差异均有统计学意义(P<0.05)。结论纳洛酮联合更昔洛韦治疗小儿病毒性脑炎的治疗效果优于纳洛酮联合病毒唑治疗,且对血清IL-1、TNF-α水平下降幅度的影响更为显著。
Objective To observe the curative effect of naloxone combined with ganciclovir and ribavirin on infantile viral encephalitis and the effects on serum levels of interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α). Methods 120 cases of children with viral encephalitis were randomly divided into experimental group and control group of 60 cases, giving all children with conventional treatment and care, the experimental group was treated with naloxone combined with ganciclovir, the control group was given naloxone In combination with ribavirin treatment, the therapeutic effects of two groups of children were evaluated after one week of treatment. Venous blood samples of two groups were collected before and after treatment to detect and evaluate the changes of serum IL-1 and TNF-α levels. Results The total effective rate in treatment group was 93.33%, which was higher than that in control group (76.67%). After treatment, the levels of IL-1 and TNF-α in serum in both groups showed a decreasing trend, but the decrease in test group was larger than that in control group There was statistical significance (P <0.05). Conclusion The treatment effect of naloxone and ganciclovir on children with viral encephalitis is better than that of naloxone combined with ribavirin, and the effect of naloxone and ganciclovir on the decrease of serum IL-1 and TNF-α levels is more significant.