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目的 通过对广东妇女选择国产Ⅰ型、国产Ⅱ型和Norplant 3种皮下埋植剂 (皮埋剂 )避孕 5年的多中心研究 ,观察避孕效果及影响结果的因素。方法 育龄妇女知情选择 3种不同的皮埋剂 ,按对象所选择的剂型分为国产Ⅰ型 2 2 9例 ,国产Ⅱ型 2 17例 ,Norplant 197例。结果 术后第 5年的粗累积寿命表续用率分别为 48 9,45 0和 63 7/10 0例妇女。国产Ⅱ型皮埋剂粗累积寿命表续用率和因月经紊乱取出率分别低于和高于国产Ⅰ型和Norplant两组。而国产Ⅰ型与Norplant两组对象的续用率和取出率之间差别无统计学意义。结论 国产Ⅰ型及Ⅱ型皮埋剂避孕效果确实 ,续用率较高 ,对性欲无明显影响 ,可取代Norplant用于我省育龄妇女避孕 ,而国产Ⅰ型明显优于国产Ⅱ型。
Objective To observe the contraceptive effect and the factors that affect the result of multicenter study on Guangdong women choosing domestic type Ⅰ, type Ⅱ and norplant 3 kinds of subcutaneous implants (embedding agent) for 5 years. Methods The women of childbearing age were informed of the choice of three different embedding agents. According to the selected dosage form, the patients were divided into two groups: domestic type Ⅰ (299 cases), domestic type Ⅱ (217) and Norplant (197 cases). Results In the fifth year after operation, the useful life of the rough accumulated life tables were 48 9,45 0 and 63 7/10 respectively. Domestic Ⅱ type burying agent of the cumulative cumulative life table continued use rate and the removal rate due to menstrual disorders were lower than and higher than the domestic type Ⅰ and Norplant two groups. However, there was no significant difference between the rate of recuperation and the rate of withdrawal between domestic Ⅰ and Norplant. CONCLUSION: The contraceptive efficacy of domestic type Ⅰ and type Ⅱ skin embedding agents is indeed high, with a higher follow-up rate and no significant effect on libido. It can replace Norplant for contraception in women of childbearing age in our province, while domestic type Ⅰ is obviously superior to domestic type Ⅱ.