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目的 :了解复方华蟾胶囊抗小鼠移植性肿瘤的作用。方法 :以小鼠肝癌 2 2 (H2 2 )、小鼠肉瘤 1 80 (S1 80 )为瘤株 ,应用动物移植性肿瘤的体内试验法对药物进行抗癌药效学试验。结果 :复方华蟾胶囊灌胃 4 ,2 g/ kg· d- 1 ,连续 14 d,对小鼠移植性肝癌实体型生长有明显的抑制作用 ,抑瘤率分别为 38.0 9% ,30 .95 %。对小鼠移植性 S1 80 实体型生长有明显的抑制作用 ,抑瘤率分别为34.7% ,30 .0 8%。复方华蟾胶囊对荷瘤小鼠的胸腺和脾脏重量无影响。结论 :复方华蟾胶囊在试验条件下有一定抗肿瘤作用
Objective : To understand the anti-tumor effect of Fufang Huayu capsule on mice. METHODS: The anti-cancer pharmacodynamics test was conducted in vivo using the animal transplantable tumor in vivo with mouse liver cancer 2 2 (H2 2) and mouse sarcoma 180 (S1 80) as tumor strains. RESULTS: Compound Huayu Capsule was given intragastrically for 4 and 2 g/kg·d- 1 for 14 days, which had a significant inhibitory effect on the growth of transplanted hepatocellular carcinoma. The tumor inhibition rates were 38.0 9% and 30.95 respectively. %. The growth of transplanted S1 80 solids was significantly inhibited in mice, and the tumor inhibition rates were 34.7% and 30.8%, respectively. Compound Huayu Capsule had no effect on the weight of thymus and spleen of tumor-bearing mice. Conclusion : Compound Huayu capsule has certain anti-tumor effect under experimental conditions