目的 探讨三体综合征患儿母亲家系流行病学调查情况,为疾病防治提供依据.方法 采用分层、不等比例、多阶段和随机整群抽样方法对400例三-体综合征患儿相关治疗进行调查分析,现场调查采用智力诊断及先天性畸形多重筛查方法进行测定,分析三体综合征患儿母亲家系流行病学情况.结果 400例三体综合征患儿中单纯21三体型构成比为45.50％,嵌合型构成比为32.25％,易位型构成比为22.25％,不同类型三体综合征构成比差异有统计学意义(P＜0.05);400例三体综合征患儿母亲家系中随着年龄的增加,三体综合征发生率呈现上升趋势;400例三体综合征患儿母亲家系中母亲年龄越大,患儿发生率越高.400例三体综合征患儿107例母亲孕前存在“暴露”情况,占26.7％,排在前2位的分别孕前持续电脑史、农药、化肥、涂料接触史,分别占38.32％和31.78％.结论 三体综合征患儿母亲家系发病率较高,应加强产妇产前诊断,降低三体综合征发生率.“,”Objective:To investigate the epidemiology of mother's family in children with trisomy syndrome,and to provide evidence for disease prevention and treatment.Methods:The investigation and Analysis on 400 cases of tfisomy syndrome were related to treatment by stratified,unequal proportion,multistage and cluster sampling method,field investigation and the intelligence diagnosis of congenital malformation multiple screening methods were determined,analysis of mothers of children with trisomy family epidemic situation.Results:the ratio was 45.50％ in 400 cases of children with trisomy 21 in only three body,accounting for 32.25％ of the ratio of 22.25％ chimeric,translocation type,different types of trisomy composition than the difference was statistically significant (P＜0.05);400 cases of trisomy of mothers of children with families with increasing age,three comprehensive the incidence rate showed an upward trend;400 cases of trisomy of mothers of children with family,mother older,children with higher incidence.400 cases of trisomy 107 cases of children with pre pregnancy are “exposed”,accounting for 26.7％,ranked in the top 2 respectively before continuing computer history,pesticide and fertilizer,coating contact history,accounting for 38.32％ and 31.78％ respectively.Conclusion:the incidence of mother's disease in children with trisomy syndrome is high,and prenatal diagnosis should be strengthened to reduce the incidence of trisomy syndrome.