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有机体的生存需要不断应对变化的环境。信号转导系统的存在有助于生物对不同的内外界信号做出相应的回应。蛋白质的磷酸化是信号转导的重要机制,二元信号转导系统(two-component signal transduction system,TCSTS)是细菌最普遍的信号转导方式,然而最早在真核生物中发现的丝氨酸、苏氨酸的磷酸化在原核生物中已成为研究的热点。丝氨酸/苏氨酸激酶与磷酸酶的协同作用与致病菌各种生命活动息息相关,包括生长,代谢,毒力以及应激压力等。本文重点介绍几种常见的链球菌中的丝/苏氨酸激酶,了解其在致病菌中的作用。鉴于真核生物STK已有大量的抑制剂被广泛使用,对链球菌真核样丝/苏氨酸激酶STK(eukaryotic-like Ser/Thr kinase,eSTK)的深入了解将有助于寻找应对链球菌感染的预防和治疗手段。
The survival of organisms needs to constantly respond to changing circumstances. The existence of the signal transduction system helps the organism to respond to different internal and external signals accordingly. Protein phosphorylation is an important mechanism of signal transduction. The two-component signal transduction system (TCSTS) is the most common signal transduction pathway of bacteria. However, the earliest serine, Phosphorylation of tryptophan in prokaryotes has become a research hotspot. The synergy between serine / threonine kinase and phosphatase is closely related to various pathogenic bacteria ’life activities, including growth, metabolism, virulence and stress. This article focuses on several common filamentous / threonine kinases in Streptococcus to understand its role in pathogenic bacteria. In view of the widespread use of STKs in eukaryotic STKs, the in-depth understanding of streptococcal eukaryotic-like Ser / Thr kinase (eSTK) Infection prevention and treatment.