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目的观察养阴清热活血方对复发性阿弗他溃疡(RAU)患者细胞因子和血液流变学的影响。方法将126例RAU患者随机分为观察组(65例)和对照组(61例);对照组给予西吡氯铵含片治疗,观察组给予西吡氯铵含片和养阴清热活血方治疗,疗程2个月。观察两组临床疗效及治疗前后细胞因子、血液流变学指标变化。结果 1观察组总有效率为92.31%,对照组为70.49%;观察组临床疗效优于对照组(P<0.05)。2治疗后,两组IL-2、INF-γ水平较治疗前上升(P<0.05),IL-6、IL-10水平明显下降(P<0.05);两组各细胞因子比较有统计学意义(P<0.05)。3治疗后,观察组血液流变学参数较治疗前明显下降(P<0.05),且观察组低于对照组(P<0.05)。结论养阴清热活血方可提高RAU临床疗效,这与其调节免疫功能、改善血液流变学有关。
Objective To observe the effects of Yangyin Qingrehuoxue recipe on cytokine and hemorheology in patients with recurrent aphthous ulcer (RAU). Methods 126 cases of RAU were randomly divided into observation group (65 cases) and control group (61 cases). The control group was treated with cetylpyridinium chloride tablets. The observation group was given cetylpyridinium chloride tablets and Yangyin Qingre Huoxue prescription , Treatment for 2 months. The clinical curative effect and changes of cytokines and hemorheology before and after treatment were observed. Results 1 The total effective rate was 92.31% in the observation group and 70.49% in the control group. The clinical efficacy of the observation group was better than that of the control group (P <0.05). After treatment, the levels of IL-2 and INF-γ in both groups were significantly increased (P <0.05) and the levels of IL-6 and IL-10 were significantly decreased in both groups (P <0.05) (P <0.05). 3 After treatment, the parameters of hemorheology in the observation group decreased significantly (P <0.05), and the observation group was lower than the control group (P <0.05). Conclusion Yangyin Qingre Huoxue Fang can improve the clinical efficacy of RAU, which is related to its regulation of immune function and improvement of hemorheology.