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目的:探讨12例胃肠道间质瘤(GIST)合并消化道癌的临床病理特征。方法:回顾性研究116例GIST,用光镜观察其中12例合并发生消化道癌的病理特征及免疫组化的表达情况。结果:GIST合并发生消化道癌的病例占所有收集GIST病例的10.34%,免疫表型CD117阳性表达10例、DOG1阳性表达11例、CD34阳性表达8例、SMA阳性表达6例,肿瘤TNM分期0期1例,Ⅰ期2例,Ⅱ期5例,Ⅲ期4例。结论:本病好发于老年男性,其中GIST多发生于胃且生物学危险度低,合并的消化道癌多为胃癌和食管癌,DOG1能帮助鉴别诊断其他胃肠道间叶源性肿瘤。
Objective: To investigate the clinicopathological features of gastrointestinal stromal tumors (GIST) in 12 cases with gastrointestinal cancer. Methods: 116 cases of GIST were retrospectively studied. The pathological features and immunohistochemical expression of 12 cases of gastrointestinal cancer were observed with light microscope. Results: GIST combined with gastrointestinal cancer accounted for 10.34% of all GIST cases. The immunophenotype CD117 positive expression was 10 cases, DOG1 positive expression was 11 cases, CD34 positive expression was 8 cases, SMA positive expression was 6 cases, tumor TNM stage was 0 1 case, 2 cases of stage Ⅰ, 5 cases of stage Ⅱ, 4 cases of stage Ⅲ. Conclusion: The disease occurs in elderly men. Among them, GIST mostly occurs in the stomach and has low biological risk. Gastric cancer and esophageal cancer are the most common gastrointestinal cancers. DOG1 can help differentiate other gastrointestinal mesenchymal tumors.