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本文报道二甲氨基偶氮苯(DAB)诱发大鼠肝癌,分别在诱癌6周、16周和32周观察血清唾液酸含量和5’—核苷酸酶(5’—NT)的动态变化。诱癌32周大鼠全部出现肝癌 在16周前未发现癌变组织。血清唾液酸在癌变前期明显降低。而当出现肝癌时则显著增高,阳性率为77％,在检出的10例混合型肝癌中则为90％。5’—核苷酸酶在16周前无明显改变,而32周出现肝癌时5’—核苷酸酶活性升高,阳性率为24％,若与唾液酸联测,可提高对肝癌检出的阳性率,血清唾液酸水平的动态变化的意义,值得进一步研究
This article reports that rat liver cancer was induced by dimethylaminoazobenzene (DAB). Serum levels of sialic acid and dynamic changes of 5′-nucleotidase (5′-NT) were observed at 6 weeks, 16 weeks, and 32 weeks respectively. . Carcinogenesis of liver cancer in 32-week-old rats No cancerous tissue was found in 16 weeks. Serum sialic acid was significantly reduced in the precancerous period. When liver cancer appeared, it was significantly higher, with a positive rate of 77%, and 90% of the 10 cases of mixed liver cancer detected. The 5’-nucleotidase did not change significantly after 16 weeks, but the 5’-nucleotidase activity was increased at 32 weeks, with a positive rate of 24%. If combined with sialic acid, it could improve the detection of liver cancer. The significance of the positive rate and the dynamic change of serum sialic acid levels deserves further study.