作者8年来选用全反式继甲酸（RA）为主要分化诱导剂，用体外细胞培养的方法，并用一系列形态学、生物学、生物化学的分子生物学的新技术和指标来研究RA对人肝癌细胞对SMMC－7721的逆转（分化诱导）作用，获得令人振奋的可喜成果。体外实验有利于药物直接作用于细胞，便于观察指 The authors selected all-trans formic acid (RA) as the main inducer of differentiation over the past 8 years, used in vitro cell culture methods, and used a series of new techniques and indicators in morphological, biological, and biochemical molecular biology to study RA on humans. The reversal (differentiation induction) effect of hepatoma cells on SMMC-7721 resulted in encouraging results. In vitro experiments facilitate the direct action of drugs on cells, facilitating observation